Projects MakingStuff Research Reference
Good SciFi and Fantasy How to Meditate Simple guide to growing mushrooms Grand Conspiracy Theories My debate style Zen FAQ Zen Center of Georgia Home
      



        


Organic Synthesis

NamedReactions

Mechanism: Wolff-Kishner Reduction



In general, the reaction mechanism first involves the in situ generation of a hydrazone by condensation of hydrazine with the ketone or aldehyde substrate. Sometimes it is however advantageous to use a pre-formed hydrazone as substrate (see modifications). The rate determining step of the reaction is de-protonation of the hydrazone by an alkoxide base to form a diimide anion by a concerted, solvent mediated protonation/de-protonation step. Collapse of this alkyldiimide with loss of N2 leads to formation of an alkylanion which can be protonated by solvent to give the desired product.



Return